Responsive Materials for Self-Regulated Insulin Delivery
نویسندگان
چکیده
منابع مشابه
Glucose-responsive insulin delivery systems.
La diabetes es un trastorno de muy alta prevalencia, caracterizado por un déficit de acción insulínica, que da lugar a concentraciones elevadas de glucosa en sangre. Las terapias sustitutivas son muy imperfectas: en pocos casos consiguen controlar de manera estable los valores de glucemia, se adaptan mal a las perturbaciones (ingestas, ejercicio, etc.), provocan hipoglucemias e implican un esfu...
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The goal of oral insulin delivery devices is to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine. In this work, we investigate the use of pH-responsive, poly(methacrylic-g-ethylene glycol) hydrogels as oral delivery vehicles for insulin. Insulin was loaded into polymeric microspheres and administered orally to healthy and diabetic W...
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ژورنال
عنوان ژورنال: Macromolecular Bioscience
سال: 2013
ISSN: 1616-5187
DOI: 10.1002/mabi.201300120